RenoCidin™ is the fermented citrus bioflavonoids manufactured through RenoSorb™ technology, standardized for highly water-soluble hesperetin phosphate. It can easily cross the oral absorption barrier in the human body and provide better bioavailability and maximized efficacy. Features include 10,000X aqueous solubility, 6X oral bioavailability, scientifically proven efficacy, a unique absorption mechanism, and recognition as a 2022 US FDA New Dietary Ingredient.

Ingredient Name: Citrus Bioflavonoid

Active Component: Hesperidin Phosphate

Functions: Supplement

Labeling Claims: Ethylene Oxide-free, GMO-free, Gluten-free, Vegan

Certifications & Compliance: FDA Compliant, GMP, Generally Recognized As Safe (GRAS), New Dietary Ingredients (NDI)

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Identification & Functionality

Active Component
Ingredient Name
Pharma & Nutraceuticals Functions

Features & Benefits

Product Highlights
  • 10,000X aqueous solubility
  • 6X oral bioavailability
  • Scientifically proven efficacy
  • Unique absorption mechanism
  • 2022 US FDA New Dietary Ingredient

Applications & Uses

Food & Nutrition Applications
Use Level
100 mg


Physical Form
Yellowish brown fine powder
Chemical Properties
ValueUnitsTest Method / Conditions
Water-soluble Hesperetin Derivativesmin. 70%QA_Q02_AH1,HPLC
Arsenic Contentmax. 2ppmMOHWH0014.03
Physical Properties
ValueUnitsTest Method / Conditions
Loss on Dryingmax. 6%QA_Q01_AH1
Microbiological Values
ValueUnitsTest Method / Conditions
Yeast & Molds Countmax. 102cfu/gMOHWM0008.01
Total Aerobic Plate Countmax. 103cfu/gMOHWM0014.01
Escherichia ColiNegative/gMOHWM0023.02
Enterobacteriamax. 10cfu/gMOHWM0028.00
Heavy Metals
ValueUnitsTest Method / Conditions
Lead Contentmax. 20ppmMOHWH0014.03

Regulatory & Compliance

Technical Details & Test Data

Pharmacokinetic Profile

RenoCidin™ - Pharmacokinetic Profile - 1
Mean plasma concentration-time profiles of hesperetin in rats after oral adminstration of native hesperidin and RenoCidin™ at 22.8 u mol/kg bw. Data are mean ‡ SE (n = 4).

Animal Study Healthy Ageing and Longevity

RenoCidin™ - Animal study Healthy Ageing and Longevity - 1
Hesperetin extends lifespan and enhances Cisd2 levels in old WT mice. The survival rate of old WT mice treated with vehicle (Veh; n = 8) or hesperetin 100 mg/kg/day (Hes; n = 19). Statistical comparison of the survival curves by log-rank test: Veh versus hesperetin, p = 0.04.

Human Study Boost Blood Flow & Circulation

RenoCidin™ - Human study Boost Blood Flow & Circulation - 1
RenoCidin™ - Human study Boost Blood Flow & Circulation - 1

Time-course of change in the skin surface temperature in cooling stress test. Value are mean SEM. **p< 0.01. RenoCidin vs placebo group (paired t-test)

Storage & Handling

Shelf Life
2 years
Storage and Shelf Life Conditions

Stored in aluminum bag at 4°C for 2 years.