RenoSage™ F50 is a fermented chrysanthemum extract produced using RenoSorb™ technology and standardized for its high water-soluble luteolin phosphate content. This formulation boasts remarkable features, including an impressive 80,000X aqueous solubility, 8.2X enhanced oral bioavailability, a solid foundation of scientifically proven efficacy, and a unique absorption mechanism. It is designed to easily traverse the oral absorption barrier within the human body, delivering superior bioavailability and maximizing its effectiveness.

Ingredient Name: Fermented Chrysanthemum Extract

Active Component: Luteolin Phosphate

Functions: Supplement

Labeling Claims: Ethylene Oxide-free, GMO-free, Gluten-free, Vegan

Certifications & Compliance: GMP, Generally Recognized As Safe (GRAS)

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Enhanced TDS

Identification & Functionality

Active Component
Pharma & Nutraceuticals Functions

Features & Benefits

Product Highlights
  • 80,000X aqueous solubility
  • 8.2X Superiod Bioavailability
  • Scientifically proven efficacy
  • Unique absorption mechanism
  • Improved the maximum plasma level of Luteolin in systemic circulation by approximately 21.5 times commerical products (2150%)

Applications & Uses

Food & Nutrition Applications
Use Level
100 - 200 mg


Physical Form
Yellow brown fine powder
Chemical Properties
ValueUnitsTest Method / Conditions
Water-soluble Luteolin Derivativesmin. 15%QA_Q02_AH1,HPLC
Arsenic Contentmax. 2ppmMOHWH0014.03
Physical Properties
ValueUnitsTest Method / Conditions
Loss on Dryingmax. 10%QA-Q01-AH1
Microbiological Values
ValueUnitsTest Method / Conditions
Yeast & Molds Countmax. 102cfu/gMOHWH0008.01
Total Aerobic Plate Countmax. 103cfu/gMOHWH0014.01
Escherichia ColiNegative/gMOHWH0023.02
Enterobacteriamax. 10cfu/gMOHWH0028.00
Heavy Metals
ValueUnitsTest Method / Conditions
Lead Contentmax. 20ppmMOHWH0014.03

Regulatory & Compliance

Certifications & Compliance

Technical Details & Test Data

Pharmacokinetic Profile

RenoSage™ F50 - Pharmacokinetic Profile - 1
Mean plasma concentration-time profiles of hesperetin in rats after oral adminstration of native hesperidin and RenoCidin™ at 22.8 u mol/kg bw. Data are mean  SE (n = 4).

Animal Study Support Cognitive & Memory Health

RenoSage™ F50 - Animal Study Support Cognitive & Memory Health - 1

RenoSage™ F50 - Animal Study Support Cognitive & Memory Health - 1

Effects of luteolin on LPS-induced cognitive learning and spatial memory impairment in Morris water maze tests. The swimming and the escape latency of mice during the Morris water maze tests. Mice received luteolin (120 mg/kg/ day) via the intragastric route for 14 days and received LPS (250 pg/kg/day) via an intraperitoneal injection for 7 days before the Morris water maze test started. A two-way ANOVA showed a difference between the Con or Lut vs. LPS (p< 0.0001).

Human Study Manage Gout and Uric Acid

RenoSage™ F50 - Human Study Manage Gout and Uric Acid - 1

Effects of luteolin on uric acid in serum of potassium oxonate (PO)-induced hyperuricemia mice. Data represent mean ‡ SEM for 10 mice. Mice were administrated with luteolin (100 mg/kg/day for 7 days, n=10) or treated with only vehicle (saline 10 ml/kg/day, n=10) as model group after PO-induced hyperuricemia in mice. ##p< 0.01 compared with normal group: **p< 0.01 compared with model group (independent samples t-test).

Packaging & Availability

Packaging Type

Storage & Handling

Shelf Life
3 years
Storage and Shelf Life Conditions

Store in aluminum bag at controlled room temperature for 3 years.