Pharm-Rx Paroxetine HCL Hemihydrate

Chemical Name: Paroxetine Hydrochloride Hemihydrate

CAS Number: 110429-35-1

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    Enhanced TDS

    Identification & Functionality

    Molecular formula
    C₁₉H₂₀FNO₃ · HCl, C₁₉H₂₀FNO₃ · HCl · ½H₂O
    Chemical Structure

    Pharm-Rx Paroxetine HCL Hemihydrate - Chemical Structure - 1


    Paroxetine Hydrochloride is anhydrous or contains one-half molecule of water of hydration. It contains NLT 98.5% and NMT 102.0% of paroxetine hydrochloride (C19H20FNO3 · HCl), calculated on the anhydrous and solvent-free basis.

    Applications & Uses


    Typical Properties
    ValueUnitsTest Method / Conditions
    Molecular Weight365.83
    Molecular Weight374.83

    Regulatory & Compliance

    USP Reference Standards

    USP Paroxetine Hydrochloride RS
    USP Paroxetine Related Compound B RS(3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-phenylpiperidine hydrochloride.
    C19H21NO3· HCl 347.84
    USP Paroxetine Related Compound C RS(3R,4S)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride;Also known as (+)-trans-Paroxetine hydrochloride.
    C19H20FNO3· HCl 365.83
    USP Paroxetine Related Compound E RS4-(4-Fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridinehydrochloride.
    C12H14FN · HCl 227.71
    [NOTE—Paroxetine related compound E was previous identified as 1-methyl-4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride.]

    USP Paroxetine Related Compound F RS (3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-1-methylpiperidine.
    C20H22FNO3 343.39

    USP Paroxetine Related Compound G RS (3SR,4RS)-3-[(Benzodioxol-5-yloxy)methyl]-4-(4′-fluorobiphenyl-4-yl)piperidine hydrochloride;Also known as(±)trans-3-[(1,3-Benzodioxol-5-yloxy) methyl]-4-(4′′-fluorophenyl-4′-phenyl)piperidine hydrochloride.
    C25H24FNO3· HCl 441.93

    USP Paroxetine System Suitability Mixture A RS
    Contains a mixture of the following three compounds: Paroxetine hydrochloride. Paroxetine related compound A: (3S,4R)-3- [(Benzodioxol-5-yloxy)methyl]-4-(4-methoxyphenyl)piperidine hydrochloride; Also known as piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-methoxyphenyl)-, hydrochloride (3S-trans)-.

    C20H23NO4∙HCl 377.86

    Paroxetine related compound B: (3S,4R)-3-[(Benzodioxol-5-yloxy)methyl]-4-phenylpiperidine hydrochloride;

    Also known as piperidine, 3-[(1,3-benzodioxol-5-yloxy)methyl]-4-phenyl-,hydrochloride (3S-trans)-.
    C19H21NO3∙HCl 347.84