Pharm-Rx Loperamide Hydrochloride

Pharm-Rx Loperamide Hydrochloride contains loperamide hydrochloride and is categorized as an active pharmaceutical Ingredient (API) within pharmaceutical actives and precursors in pharmaceuticals and nutraceuticals technologies. Loperamide hydrochloride is a significant compound utilized in various pharmaceutical formulations for its antidiarrheal properties.

Chemical Name: Loperamide Hydrochloride

CAS Number: 34552-83-5

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    Enhanced TDS

    Identification & Functionality

    Molecular formula
    C₂₉H₃₃ClN₂O₂ · HCl

    Loperamide Hydrochloride contains not less than 98.0% and not more than 102.0% of loperamide hydrochloride (C₂₉H₃₃ClN₂O₂ · HCl), calculated on the dried basis.

    Chemical Structure

     - 1

    Applications & Uses

    Regulatory & Compliance

    USP Reference Standards
    • USP Loperamide Hydrochloride RS USP Loperamide System Suitability Mixture RS The mixture contains loperamide hydrochloride and the following impurities (other impurities may also be present): Chlorophenylpiperidinol; 4-(4-Chlorophenyl)piperidin-4-ol
    • C11H14ClNO 211.69 Deschloroloperamide; 4-(4-Hydroxy-4-phenylpiperidin-1-yl)-N,N-dimethyl-2,2- diphenylbutanamide
    • C29H34N2O2 442.59 Loperamide trans-N-oxide; (1r,4s)-4-(4-Chlorophenyl)-1-[4-(dimethylamino)-4-oxo- 3,3-diphenylbutyl]-4-hydroxypiperidine 1-oxide
    • C29H33ClN2O3 493.04 Loperamide cis-N-oxide; (1s,4r)-4-(4-Chlorophenyl)-1-[4-(dimethylamino)-4-oxo- 3,3-diphenylbutyl]-4-hydroxypiperidine 1-oxide
    • C29H33ClN2O3 493.04 Anhydroloperamide; 4-[4-(4-Chlorophenyl)-5,6-dihydropyridin-1(2H)-yl]-N,N- dimethyl-2,2-diphenylbutanamide
    • C29H31ClN2O 459.02 Loperamide piperidinolamide; 1,4-Bis[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2- diphenylbutan-1-one
    • C38H40Cl2N2O3 643.64 Loperamide biphenyl analog; 4-[4-(4′-Chlorobiphenyl-4-yl)-4-hydroxypiperidin-1-yl]- N,N-dimethyl-2,2-diphenylbutanamide
    • C35H37ClN2O2 553.13 Loperamide quaternary salt; 4-(4-Chlorophenyl)-1,1-bis[4-(dimethylamino)-4-oxo- 3,3-diphenylbutyl]-4-hydroxypiperidin-1-ium chloride
    • C47H53Cl2N3O3 778.85 (USP 1-May-2020)

    Storage & Handling

    Storage Information

    Preserve in well-closed containers. Change to read: